The 14q+ Chromosome in Pre-B-ALL

A child who had acute lymphoblastic leukemia (ALL) associated with an 8;14 chromosome translocation and with a pre-B phenotype is described. The leukemic cells were determined to be pre-B-cells on the basis of intracytoplasmic µ-chain immunoglobulin (cIgM +) and the common-ALL antigen, lack of recep...

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Bibliographic Details
Published in:Blood 1980-11, Vol.56 (5), p.782-785
Main Authors: Kaneko, Yasuhiko, Rowley, Janet D., Check, Irene, Variakojis, Daina, Moohr, John W.
Format: Article
Language:English
Subjects:
B-Lymphocytes - immunology
Child
Chromosomes, Human, 13-15
Chromosomes, Human, 6-12 and X
Humans
Leukemia, Lymphoid - immunology
Leukemia, Lymphoid - pathology
Male
Phenotype
Translocation, Genetic
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Summary:A child who had acute lymphoblastic leukemia (ALL) associated with an 8;14 chromosome translocation and with a pre-B phenotype is described. The leukemic cells were determined to be pre-B-cells on the basis of intracytoplasmic µ-chain immunoglobulin (cIgM +) and the common-ALL antigen, lack of receptors for sheep erythrocytes, and lack of surface immunoglobulin. The 8;14 translocation is frequently found in patients with Burkitt’s lymphoma and in most patients with B-cell ALL and is known to carry a poor prognosis. Thus far, no karyotypes have been reported for patients with pre-B-ALL. The present case indicates that a 14q + chromosome may provide a proliferative advantage not only to cells with a B-cell phenotype, but also to pre-B-cells. The short survival of our patient also suggests that the 14q + abnormality and the pre-B phenotype may signal a poor prognosis.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V56.5.782.782