Ferrioxamine Excretion in Iron-Loaded Man

Factors affecting iron excretion after subcutaneous desferrioxamine infusion were evaluated in individuals with iron overload. Urinary iron varied directly, whereas stool iron varied inversely with the level of erythropoiesis. Ascorbic acid greatly enhanced urinary iron excretion but had a less cons...

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Bibliographic Details
Published in:Blood 1982-08, Vol.60 (2), p.288-294
Main Authors: Pippard, Martin J., Callender, Sheila T., Finch, Clement A.
Format: Article
Language:English
Subjects:
Adult
Ascorbic Acid - therapeutic use
Deferoxamine - therapeutic use
Dose-Response Relationship, Drug
Feces - analysis
Hemosiderosis - drug therapy
Hemosiderosis - etiology
Hemosiderosis - urine
Humans
Intestinal Absorption
Iron - urine
Thalassemia - complications
Transfusion Reaction
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Summary:Factors affecting iron excretion after subcutaneous desferrioxamine infusion were evaluated in individuals with iron overload. Urinary iron varied directly, whereas stool iron varied inversely with the level of erythropoiesis. Ascorbic acid greatly enhanced urinary iron excretion but had a less constant effect on stool iron. Stool iron losses contributed a greater proportion of total iron excretion at higher chelator dosage. These studies indicate the importance of biliary iron excretion in monitoring the effectiveness of desferrioxamine. They also suggest that large chelator doses may remove established iron overload much more rapidly than has previously been realized.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V60.2.288.288