Human Large Granular Lymphocytes and Their Relationship to Natural Killer Cell Activity in Various Disease States

This study investigated the numbers of large granular lymphocytes (LGL) and their relationship to natural killer (NK) function, as assessed by their capacity to lyse the human tumor target, K562. Peripheral blood mononuclear cells from 42 normal controls and from 171 patients suffering from various...

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Bibliographic Details
Published in:Blood 1984-07, Vol.64 (1), p.288-295
Main Authors: Gastl, Günther, Niederwieser, Dietger, Marth, Christian, Huber, Heinz, Egg, Dietmar, Schuler, Gerold, Margreiter, Raimund, Braunsteiner, Herbert, Huber, Christoph
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anemia, Aplastic - immunology
Autoimmune Diseases - immunology
Bone Marrow Diseases - immunology
Bone Marrow Transplantation
Cell Communication
Cell Line
Cyclophosphamide - therapeutic use
Female
Humans
Kidney Transplantation
Killer Cells, Natural - immunology
Leukocyte Count
Lymphocytes - immunology
Male
Middle Aged
Neoplastic Stem Cells - immunology
Neoplastic Stem Cells - ultrastructure
Whole-Body Irradiation
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Summary:This study investigated the numbers of large granular lymphocytes (LGL) and their relationship to natural killer (NK) function, as assessed by their capacity to lyse the human tumor target, K562. Peripheral blood mononuclear cells from 42 normal controls and from 171 patients suffering from various nonmalignant or malignant diseases were evaluated. Also studied were samples from a patient undergoing autologous bone marrow reconstitution following total body irradiation. Results suggested the existence of a close relationship between the numbers of LGL and the capacity to lyse K562 targets, further supporting the view that LGL are crucial effector cells mediating NK lysis. In certain diseases, such as malignant states, functional capacity was not simply determined by the numbers of LGL. Here preferential reduction of the capacity to lyse K562 targets was observed, indicating that additional limiting factors are involved in the determination of the cytotoxic potential. Based on the relationship between LGL and natural immune functions, as well as on the identification of leukemias affecting this cell type, we would recommend their evaluation on a large scale clinical basis.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V64.1.288.288