Plasminogen Activator Inhibitor: A Regulator of Ancrod-Induced Fibrin Deposition in Rabbits

Plasma levels of a fast-acting plasminogen activator inhibitor (PAI), which neutralizes both tissue plasminogen activator (t-PA) and urokinase, are markedly increased in endotoxin-treated rabbits. The ability of this inhibitor to prevent the fibrinolysis that occurs after a thrombogenic stimulus was...

Full description

Saved in:
Bibliographic Details
Published in:Blood 1987-03, Vol.69 (3), p.798-803
Main Authors: Krishnamurti, Chitra, Barr, Charles F., Hassett, M. Alycia, Young, G. David, Alving, Barbara M.
Format: Article
Language:English
Subjects:
Ancrod - pharmacology
Ancrod - toxicity
Animals
Biological and medical sciences
Blood coagulation. Blood cells
Endotoxins - toxicity
Fibrin - metabolism
Fibrinolysis - drug effects
Fundamental and applied biological sciences. Psychology
General aspects, investigation methods, hemostasis, fibrinolysis
Glycoproteins - pharmacology
Male
Molecular and cellular biology
Plasminogen Inactivators
Rabbits
Thrombosis - chemically induced
Tissue Plasminogen Activator - antagonists & inhibitors
Urokinase-Type Plasminogen Activator - antagonists & inhibitors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Plasma levels of a fast-acting plasminogen activator inhibitor (PAI), which neutralizes both tissue plasminogen activator (t-PA) and urokinase, are markedly increased in endotoxin-treated rabbits. The ability of this inhibitor to prevent the fibrinolysis that occurs after a thrombogenic stimulus was investigated in a rabbit model. Normal and endotoxin-treated male New Zealand rabbits were infused with ancrod, an enzyme that causes noncrosslinked fibrin formation in vivo. Ancrod stimulated t-PA activity by 90% in normal rabbits and caused hypofibrinogenemia but did not increase PAI levels or induce fibrin deposition in target organs. Rabbits injected with endotoxin (10 Mg/kg) showed an increase in PAI from
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V69.3.798.798