Intermediate- to High-Grade Histology of Lymphomas Carrying t(14;18) Is Associated With Additional Nonrandom Chromosome Changes

We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin' x2018;s lymphoma (NHL) bearing t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1,1984, to Dece...

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Bibliographic Details
Published in:Blood 1987-08, Vol.70 (2), p.444-447
Main Authors: Richardson, Mark E., Quanguang, Chen, Filippa, Daniel A., Offit, Kenneth, Hampton, Alice, Koduru, Prasad R.K., Jhanwar, Suresh C., Lieberman, Philip H., Clarkson, Bayard D., Chaganti, R.S.K.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cell Transformation, Neoplastic - genetics
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Female
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - genetics
Lymphoma, Non-Hodgkin - pathology
Male
Medical sciences
Middle Aged
Recurrence
Translocation, Genetic
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Summary:We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin' x2018;s lymphoma (NHL) bearing t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1,1984, to December 31,1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying t(14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V70.2.444.444