Iron absorption in hypotransferrinemic mice

We used a unique animal model, the hypotransferrinemic (Htx) mouse, to examine the role of transferrin (Tf) in gastrointestinal iron uptake. Despite the absence of Tf, Htx animals hyperabsorb iron. Transfusion of red blood cells sufficient to normalize the hematocrit and reticulocyte count resulted...

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Bibliographic Details
Published in:Blood 1991-12, Vol.78 (12), p.3288-3290
Main Authors: BUYS, S. S, MARTIN, C. B, ELDRIDGE, M, KUSHNER, J. P, KAPLAN, J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Transfusion
Enzyme-Linked Immunosorbent Assay
Erythrocyte Count
Erythrocyte Transfusion
Hematocrit
Hematologic and hematopoietic diseases
Intestinal Absorption
Iron - metabolism
Medical sciences
Mice
Mice, Mutant Strains
Other diseases. Hematologic involvement in other diseases
Reticulocytes - cytology
Transferrin - deficiency
Transferrin - physiology
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Summary:We used a unique animal model, the hypotransferrinemic (Htx) mouse, to examine the role of transferrin (Tf) in gastrointestinal iron uptake. Despite the absence of Tf, Htx animals hyperabsorb iron. Transfusion of red blood cells sufficient to normalize the hematocrit and reticulocyte count resulted in a return of iron absorption to normal values. These studies indicate that Tf does not play an obligate role in iron absorption, either as a carrier or as a humoral signal regulating absorption. Transfer of plasma or whole blood from Htx mice or from other animal models of iron hyperabsorption to normal mice did not cause an increase in iron absorption in recipient animals. Using the plasma or blood transfer approach, we have been unable to detect a humoral regulator of gastrointestinal iron absorption.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.v78.12.3288.3288