Pivotal Role of the B7:CD28 Pathway in Transplantation Tolerance and Tumor Immunity

The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that modulation of the B7:CD28 pathway will result in either amplification or suppression of the immune response. Considering the frequency with which...

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Bibliographic Details
Published in:Blood 1994-11, Vol.84 (10), p.3261-3282
Main Authors: Guinan, Eva C., Gribben, John G., Boussiotis, Vicki A., Freeman, Gordon J., Nadler, Lee M.
Format: Article
Language:English
Subjects:
Abatacept
Antigen-Presenting Cells - immunology
Antigens, CD - immunology
Antigens, Differentiation - immunology
B7-1 Antigen - immunology
Biological and medical sciences
CD28 Antigens - immunology
CTLA-4 Antigen
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Immunoconjugates
Immunosuppression
Models, Biological
Modulation of the immune response (stimulation, suppression)
Neoplasms - immunology
T-Lymphocytes - immunology
Transplantation Immunology
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Summary:The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that modulation of the B7:CD28 pathway will result in either amplification or suppression of the immune response. Considering the frequency with which diseases characterized by either inadequate or dysregulated immune function present to the practicing hematologist or oncologist, it is not difficult to envisage clinical applications for reagents that modulate this pathway. However, we still have much to learn about the function and clinical potential of this and other potentially redundant costimulatory pathways and therefore we suspect that this story will become considerably more complex over the next few years.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V84.10.3261.3261