Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle

Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated a...

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Bibliographic Details
Published in:Blood 1994-11, Vol.84 (10), p.3457-3464
Main Authors: Goodman, MG, Wormsley, SB, Spinosa, JC, Piro, LD
Format: Article
Language:English
Online Access:Get full text
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Summary:Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated and undergo DNA synthesis and mitosis accompanied by a marked increase in expression of an array of cell surface activation antigens. The resultant activated B-CLL cells exhibit greatly enhanced sensitivity to cycle-active cytotoxic drugs. This approach may be of potential value in the therapy of CLL.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V84.10.3457.bloodjournal84103457