Determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis

• Published in: Current medical research and opinion 2008-05, Vol.24 (5), p.1337-1344
• Main Authors: Penning-van Beest, Fernie J. A., Erkens, Joëlle A., Olson, M., Herings, Ron M. C.
• Format: Article
• Language: English
• Subjects: Aged; Alendronate - administration & dosage; Analysis of Variance; Bisphosphonates; Bone Density - drug effects; Co-medication; Cohort Studies; Databases, Factual; Determinants; Diphosphonates - administration & dosage; Dose-Response Relationship, Drug; Dosing frequency; Drug Administration Schedule; Etidronic Acid - administration & dosage; Etidronic Acid - analogs & derivatives; Female; Humans; Logistic Models; Middle Aged; Netherlands; Non-compliance; Osteoporosis; Osteoporosis, Postmenopausal - diagnosis; Osteoporosis, Postmenopausal - drug therapy; Osteoporosis, Postmenopausal - epidemiology; Patient Compliance - statistics & numerical data; Probability; Prognosis; Retrospective Studies; Risedronic Acid; Risk Factors; Severity of Illness Index; Treatment Outcome; Treatment Refusal - statistics & numerical data
• ISSN: 0300-7995; 1473-4877
• DOI: 10.1185/030079908X297358

ABSTRACT Objective: To identify determinants of non-compliance with bisphosphonates in women with postmenopausal osteoporosis. By considering the year of the introduction of weekly bisphosphonates important additional information is obtained. Methods: New female users of daily or weekly alendronate or risedronate between 1999 and 2004, aged ≥ 45 years were identified from PHARMO RLS, including drug-dispensing and hospitalisation data of > 2 million residents of the Netherlands. One-year compliance with bisphosphonates was measured using the Medication Possession Ratio (MPR). To identify determinants of non-compliance, non-compliant women (MPR