Alcoholic lung injury: pineapple peel extract modulates antioxidant enzymes and attenuates lipid peroxidation in rat models

Background The therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated. GC – MS was used in characterizing secondary metabolites of the extracts. Methods Oxidative stress was induced by oral administration of ethan...

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Bibliographic Details
Published in:Clinical phytoscience 2016-06, Vol.2 (1), Article 14
Main Authors: Erukainure, Ochuko L., Ajiboye, John A., Okafor, Oluwatoyin Y., Okoro, Emeka E., Asieba, Godfrey, Sarumi, Bolanle B., Adenekan, Sunday O., Zaruwa, Moses Z.
Format: Article
Language:English
Subjects:
Diabetes
Gastroenterology
Gynecology
Medicine
Medicine & Public Health
Original Contribution
Pediatrics
Pneumology/Respiratory System
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Summary:Background The therapeutic potentials of the methanolic extract of pineapple peel against alcohol – induced lung injury in male albino rats was investigated. GC – MS was used in characterizing secondary metabolites of the extracts. Methods Oxidative stress was induced by oral administration of ethanol (20 %  w/v ) at a dosage of 5 mL/kg body weight in rats. After 28 days of treatment, the rats were fasted overnight and sacrificed by cervical dislocation. Lung tissue homogenates were used for the assessment of protein concentration, reduced glutathione (GSH), catalase, superoxide dismutase (SOD) and lipid peroxidation. Results GCMS analysis revealed the presence of 10 compounds with ethanimidic acid, ethyl ester (32.52 %) being the most predominant compound. Ingestion of alcohol led to a significant ( p  
ISSN:2199-1197
2199-1197
DOI:10.1186/s40816-016-0026-3