Mitochondrial Dysfunction Is a Common Phenotype in Aging and Cancer

: An interesting clue with regard to molecular mechanisms underlying age‐associated cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a progressive decline in mitochondrial function during aging. Studies have established that the decline in mitochondrial function i...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-06, Vol.1019 (1), p.260-264
Main Author: SINGH, KESHAV K.
Format: Article
Language:English
Subjects:
Aging
Animals
Apoptosis
Caenorhabditis elegans
cancer
Cell Nucleus - metabolism
DNA, Mitochondrial - metabolism
Genome
Genotype
Humans
Mitochondria - pathology
mitochondrial DNA (mtDNA)
mitochondrial dysfunction
Mutation
Neoplasms - pathology
Oxidative Stress
Phenotype
Saccharomyces cerevisiae - metabolism
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Summary:: An interesting clue with regard to molecular mechanisms underlying age‐associated cancers is the apparent defect in mitochondrial function. Recent studies demonstrate a progressive decline in mitochondrial function during aging. Studies have established that the decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. These observations suggest that the mitochondrial dysfunction that accompanies aging may exert a major influence on carcinogenesis.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1297.043