Gene Expression Induced by X-ray Irradiation in Human Blood Cell Lines

: The response to X‐ray irradiation of three different human hematopoietic cell lines originating from T (Jurkat), B (Raji), and promyelocytic (HL60) leukemia was analyzed. The survival after irradiation differed among the three cell lines, with Jurkat cells being the most vulnerable and HL60 being...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2003-12, Vol.1010 (1), p.339-341
Main Authors: MORI, M, BENOTMANE, M A., VERHEYDE, J, VAN HUMMELEN, P, HOOGHE-PETERS, E L., DESAINTES, C
Format: Article
Language:English
Subjects:
Cell Line
Cell Line, Tumor
Cell Survival - radiation effects
Dose-Response Relationship, Radiation
Gene Expression Regulation, Neoplastic - radiation effects
HL-60 Cells
HL60
Humans
irradiation
Jurkat
Jurkat Cells
Raji
X rays
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Summary:: The response to X‐ray irradiation of three different human hematopoietic cell lines originating from T (Jurkat), B (Raji), and promyelocytic (HL60) leukemia was analyzed. The survival after irradiation differed among the three cell lines, with Jurkat cells being the most vulnerable and HL60 being the least sensitive. The profile of gene expression was studied with the microarray technique in both Jurkat and HL60 cell lines. Out of the 13,800 different genes spotted on microarrays, very few genes (
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1299.061