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Endogenous β-Carbolines as Clonidine-Displacing Substances

: Endogenous β‐carbolines, such as harmane, are known to occur in mammalian species including humans. Radioligand binding studies have revealed that certain β‐carbolines display high affinity for both I1 and I2 imidazoline‐binding sites (IBS). Functional studies have shown that the β‐carboline harma...

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Published in:	Annals of the New York Academy of Sciences 2003-12, Vol.1009 (1), p.157-166
Main Authors:	ROBINSON, ESJ, ANDERSON, NJ, CROSBY, J, NUTT, DJ, HUDSON, AL
Format:	Article
Language:	English
Subjects:	Adrenergic alpha-Agonists - chemistry Adrenergic alpha-Agonists - metabolism Animals b-carboline Carbolines - chemistry Carbolines - metabolism Clonidine - analogs & derivatives Clonidine - metabolism clonidine-displacing substance (CDS) harmane Harmine - analogs & derivatives Harmine - chemistry Harmine - metabolism Humans Ligands Molecular Structure Radioligand Assay Signal Transduction
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creator	ROBINSON, ESJ ANDERSON, NJ CROSBY, J NUTT, DJ HUDSON, AL
description	: Endogenous β‐carbolines, such as harmane, are known to occur in mammalian species including humans. Radioligand binding studies have revealed that certain β‐carbolines display high affinity for both I1 and I2 imidazoline‐binding sites (IBS). Functional studies have shown that the β‐carboline harmane elicits many characteristics expected of an endogenous ligand IBS. This article discusses the evidence relating to β‐carbolines as endogenous ligands and presents a case for harmane and related compounds as endogenous ligands for IBS.
doi_str_mv	10.1196/annals.1304.018
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subjects	Adrenergic alpha-Agonists - chemistry Adrenergic alpha-Agonists - metabolism Animals b-carboline Carbolines - chemistry Carbolines - metabolism Clonidine - analogs & derivatives Clonidine - metabolism clonidine-displacing substance (CDS) harmane Harmine - analogs & derivatives Harmine - chemistry Harmine - metabolism Humans Ligands Molecular Structure Radioligand Assay Signal Transduction
title	Endogenous β-Carbolines as Clonidine-Displacing Substances
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