Effects of Metal Ions on Plasma Membrane Mg 2+ ‐ATPase in Rat Uterus and Ovaries

A bstract : The in vitro effects of cadmium and mercury were investigated on the Mg 2+ ‐ATPase activity of plasma membranes from the rat ovary and uterus. ATP hydrolyzing activities were significant and dose‐dependent‐inhibited in both plasma membrane preparations by both metals. According to the IC...

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Published in:Annals of the New York Academy of Sciences 2005-06, Vol.1048 (1), p.445-448
Main Authors: MILOŠEVIĆ, MAJA, PETROVIĆ, SNJEŽANA, DEMAJO, MIROSLAV, HORVAT, ANICA
Format: Article
Language:English
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Summary:A bstract : The in vitro effects of cadmium and mercury were investigated on the Mg 2+ ‐ATPase activity of plasma membranes from the rat ovary and uterus. ATP hydrolyzing activities were significant and dose‐dependent‐inhibited in both plasma membrane preparations by both metals. According to the IC 50 and apparent K i , Cd 2+ was most potent in the ovary, while Hg 2+ was most potent in the uterus. In ovaries and uterus, Cd 2+ inhibits competitively, while Hg 2+ inhibits noncompetitively in both organs. The observed inhibition was a consequence of direct action of the chosen metal ions on the enzyme protein and by decreasing ATP hydrolysis, Hg 2+ and Cd 2+ may affect mammalian fertility.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1342.061