Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs

Death from an accidental or intentional overdose of sleeping tablets has increased exponentially in the USA. Furthermore, the simultaneous consumption of sleeping tablets with alcoholic beverages not only intensifies the effect of sleeping tablets but also leads to blackouts, sleepwalking, and death...

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Bibliographic Details
Published in:AAPS PharmSciTech 2020-11, Vol.22 (1), p.9, Article 9
Main Authors: Patki, Manali, Palekar, Siddhant, Nukala, Pavan Kumar, Vartak, Richa, Patel, Ketankumar
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Overdose
Ethanol - administration & dosage
Humans
Pharmacology/Toxicology
Pharmacy
Polymers - chemistry
Polymethacrylic Acids
Research Article
Sleep Aids, Pharmaceutical - administration & dosage
Solubility
Tablets
Theme: Pharmaceutical Thermal Processing - An Update
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Summary:Death from an accidental or intentional overdose of sleeping tablets has increased exponentially in the USA. Furthermore, the simultaneous consumption of sleeping tablets with alcoholic beverages not only intensifies the effect of sleeping tablets but also leads to blackouts, sleepwalking, and death in many cases. In this article, we proposed a unique and innovative technology to prevent multi-tablet and alcohol-associated abuse of sleeping tablet. Agonist- and antagonist-loaded polymeric filaments of appropriate Eudragit® polymers were prepared using hot melt extrusion. Metoprolol tartrate and hydrochlorothiazide were used as model drugs in place of zolpidem tartrate (agonist-BCS class I) and flumazenil (antagonist-BCS class IV), respectively. Crushed filaments were converted into a tablet with a novel rapidly soluble co-processed alkalizing agent. Dissolution studies of single tablet and multiple tablets (5) in fasted state simulated gastric fluid (FaSSGF) confirmed that the release of the agonist was significantly ( p  
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-020-01879-7