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Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water
GH has a strong influence on body composition. However, the effects of GH deficiency in adults on water compartments are not well understood. Therefore, extracellular water (ECW) and total body water were independently determined by deuterium and bromide dilution and by bioimpedance spectrometry in...
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Published in: | The journal of clinical endocrinology and metabolism 1997-03, Vol.82 (3), p.907-911 |
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container_title | The journal of clinical endocrinology and metabolism |
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creator | van Marken Lichtenbelt, Wouter D Snel, Yvonne E. M Brummer, Robert-Jan M Koppeschaar, Hans P. F |
description | GH has a strong influence on body composition. However, the effects of
GH deficiency in adults on water compartments are not well understood.
Therefore, extracellular water (ECW) and total body water were
independently determined by deuterium and bromide dilution and by
bioimpedance spectrometry in GH-deficient (GHD) adults and compared to
those in controls, matched for age, sex, body weight, and height.
The results show that the percent body fat was significantly
(P < 0.05) higher, and total body water and
intracellular water (ICW) were significantly lower in GHD adults for
males, females, and both sexes combined. ECW was not significantly
different between the two groups. ECW/ICW in GHD adults (0.42 ±
0.03) was significantly (P < 0.01) higher than
that in controls (0.39 ± 0.02). There was a significant positive
relation between the ECW/ICW ratio and the percent body fat. These
results were confirmed by the bioimpedance spectrometry measurements. |
doi_str_mv | 10.1210/jcem.82.3.3833 |
format | article |
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GH deficiency in adults on water compartments are not well understood.
Therefore, extracellular water (ECW) and total body water were
independently determined by deuterium and bromide dilution and by
bioimpedance spectrometry in GH-deficient (GHD) adults and compared to
those in controls, matched for age, sex, body weight, and height.
The results show that the percent body fat was significantly
(P < 0.05) higher, and total body water and
intracellular water (ICW) were significantly lower in GHD adults for
males, females, and both sexes combined. ECW was not significantly
different between the two groups. ECW/ICW in GHD adults (0.42 ±
0.03) was significantly (P < 0.01) higher than
that in controls (0.39 ± 0.02). There was a significant positive
relation between the ECW/ICW ratio and the percent body fat. These
results were confirmed by the bioimpedance spectrometry measurements.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jcem.82.3.3833</identifier><identifier>PMID: 9062505</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Biological and medical sciences ; Body Water - metabolism ; Bromides ; Deuterium Oxide ; Electric Impedance ; Extracellular Space - metabolism ; Female ; Functional investigation of endocrine glands and genital system ; Human Growth Hormone - deficiency ; Humans ; Indicator Dilution Techniques ; Intracellular Membranes - metabolism ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Sodium Compounds</subject><ispartof>The journal of clinical endocrinology and metabolism, 1997-03, Vol.82 (3), p.907-911</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-983cb93c8ae6816a4ee9c150e2abaa92bb41998e48cf2fd6b9829c5a698088623</citedby><cites>FETCH-LOGICAL-c374t-983cb93c8ae6816a4ee9c150e2abaa92bb41998e48cf2fd6b9829c5a698088623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2618146$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9062505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Marken Lichtenbelt, Wouter D</creatorcontrib><creatorcontrib>Snel, Yvonne E. M</creatorcontrib><creatorcontrib>Brummer, Robert-Jan M</creatorcontrib><creatorcontrib>Koppeschaar, Hans P. F</creatorcontrib><title>Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>GH has a strong influence on body composition. However, the effects of
GH deficiency in adults on water compartments are not well understood.
Therefore, extracellular water (ECW) and total body water were
independently determined by deuterium and bromide dilution and by
bioimpedance spectrometry in GH-deficient (GHD) adults and compared to
those in controls, matched for age, sex, body weight, and height.
The results show that the percent body fat was significantly
(P < 0.05) higher, and total body water and
intracellular water (ICW) were significantly lower in GHD adults for
males, females, and both sexes combined. ECW was not significantly
different between the two groups. ECW/ICW in GHD adults (0.42 ±
0.03) was significantly (P < 0.01) higher than
that in controls (0.39 ± 0.02). There was a significant positive
relation between the ECW/ICW ratio and the percent body fat. These
results were confirmed by the bioimpedance spectrometry measurements.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Body Water - metabolism</subject><subject>Bromides</subject><subject>Deuterium Oxide</subject><subject>Electric Impedance</subject><subject>Extracellular Space - metabolism</subject><subject>Female</subject><subject>Functional investigation of endocrine glands and genital system</subject><subject>Human Growth Hormone - deficiency</subject><subject>Humans</subject><subject>Indicator Dilution Techniques</subject><subject>Intracellular Membranes - metabolism</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sodium Compounds</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNp1kU9v1DAQxS0EKtvClRuSDxxJ8J8kax_L7rZbqRISLYJb5DgT1qvYjmyHsh-Q74VXu-oFcbGlmd-bsd9D6B0lJWWUfNprsKVgJS-54PwFWlBZ1cWSyuVLtCCE0UIu2Y_X6DLGPSG0qmp-gS4kaVhN6gX6s4Y5QTCzxcr1-HPw1vSA12ack_Hu46lqvLET9MppwA8T6JQxSOGA71wPE-TDpfGAH3b-CT_uVMK3wT-lHd76YL2DYg2D0SZD-LqfxxTxVv2CPBpv3KjCT-jx5ncKSsM4zrmAv6v8JrzydlIh2aPuK4y51uPk885_0Dfo1aDGCG_P9xX6drN5XG2L-y-3d6vr-0LzZZUKKbjuJNdCQSNooyoAqWlNgKlOKcm6rqJSCqiEHtjQN50UTOpaNVIQIRrGr1B5mquDjzHA0E7BWBUOLSXtMY72GEcrWMvbYxxZ8P4kmObOQv-Mn_3P_Q_nvopajUPIFpv4jLGGClo1GatPWLba62AcTAFibPd-Di5_-H_r_wJciqqX</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>van Marken Lichtenbelt, Wouter D</creator><creator>Snel, Yvonne E. M</creator><creator>Brummer, Robert-Jan M</creator><creator>Koppeschaar, Hans P. F</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19970301</creationdate><title>Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water</title><author>van Marken Lichtenbelt, Wouter D ; Snel, Yvonne E. M ; Brummer, Robert-Jan M ; Koppeschaar, Hans P. F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-983cb93c8ae6816a4ee9c150e2abaa92bb41998e48cf2fd6b9829c5a698088623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Body Water - metabolism</topic><topic>Bromides</topic><topic>Deuterium Oxide</topic><topic>Electric Impedance</topic><topic>Extracellular Space - metabolism</topic><topic>Female</topic><topic>Functional investigation of endocrine glands and genital system</topic><topic>Human Growth Hormone - deficiency</topic><topic>Humans</topic><topic>Indicator Dilution Techniques</topic><topic>Intracellular Membranes - metabolism</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Sodium Compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Marken Lichtenbelt, Wouter D</creatorcontrib><creatorcontrib>Snel, Yvonne E. M</creatorcontrib><creatorcontrib>Brummer, Robert-Jan M</creatorcontrib><creatorcontrib>Koppeschaar, Hans P. F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Marken Lichtenbelt, Wouter D</au><au>Snel, Yvonne E. M</au><au>Brummer, Robert-Jan M</au><au>Koppeschaar, Hans P. F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1997-03-01</date><risdate>1997</risdate><volume>82</volume><issue>3</issue><spage>907</spage><epage>911</epage><pages>907-911</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>GH has a strong influence on body composition. However, the effects of
GH deficiency in adults on water compartments are not well understood.
Therefore, extracellular water (ECW) and total body water were
independently determined by deuterium and bromide dilution and by
bioimpedance spectrometry in GH-deficient (GHD) adults and compared to
those in controls, matched for age, sex, body weight, and height.
The results show that the percent body fat was significantly
(P < 0.05) higher, and total body water and
intracellular water (ICW) were significantly lower in GHD adults for
males, females, and both sexes combined. ECW was not significantly
different between the two groups. ECW/ICW in GHD adults (0.42 ±
0.03) was significantly (P < 0.01) higher than
that in controls (0.39 ± 0.02). There was a significant positive
relation between the ECW/ICW ratio and the percent body fat. These
results were confirmed by the bioimpedance spectrometry measurements.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>9062505</pmid><doi>10.1210/jcem.82.3.3833</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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issn | 0021-972X 1945-7197 |
language | eng |
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source | Oxford Journals Online |
subjects | Adult Biological and medical sciences Body Water - metabolism Bromides Deuterium Oxide Electric Impedance Extracellular Space - metabolism Female Functional investigation of endocrine glands and genital system Human Growth Hormone - deficiency Humans Indicator Dilution Techniques Intracellular Membranes - metabolism Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Sodium Compounds |
title | Deuterium and Bromide Dilution, and Bioimpedance Spectrometry Independently Show That Growth Hormone-Deficient Adults Have an Enlarged Extracellular Water Compartment Related to Intracellular Water |
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