Relationship between the GH/IGF-I Axis, Insulin Sensitivity, and Adrenal Androgens in Normal Prepubertal and Pubertal Boys

In girls, but not in boys, pronounced adrenarche and precocious pubarche along with ovarian hyperandrogenism have been related to insulin resistance and reduced fetal growth. However, insulin secretion is increased during puberty in normal boys. The aim of this study was to analyze the possible impl...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2002-03, Vol.87 (3), p.1162-1169
Main Authors: Guercio, Gabriela, Rivarola, Marco A., Chaler, Eduardo, Maceiras, Mercedes, Belgorosky, Alicia
Format: Article
Language:English
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Summary:In girls, but not in boys, pronounced adrenarche and precocious pubarche along with ovarian hyperandrogenism have been related to insulin resistance and reduced fetal growth. However, insulin secretion is increased during puberty in normal boys. The aim of this study was to analyze the possible implication of changes in the GH/IGF-I axis and in insulin sensitivity for the regulation of adrenal androgen secretion of normal prepubertal and adolescent boys. Fifty-six normal boys were divided into the following groups (Gr): Gr1, prepuberty (testicular volume,
ISSN:0021-972X
1945-7197
DOI:10.1210/jcem.87.3.8330