Substituted 2-Amidomethyl[1,4]benzodioxins: Synthesis and Binding Affinity for the Melatonin Receptors

A novel series of melatonin analogues based on the benzodioxin nucleus is described. The compounds were prepared in several steps from 2‐carbethoxy‐1,4‐benzodioxin. Some of these derivatives competitively inhibited 2‐[125I]‐iodomelatonin binding to chicken brain and ovine pars tuberalis membranes, a...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacy and Pharmacology Communications 1999-03, Vol.5 (3), p.199-206
Main Authors: MAMAI, A., BENNEJEAN, C., RENARD, P., DELAGRANGE, P., GUARDIOLA-LEMAITRE, B., HOWELL, H. E., VIAUD, M. C., GUILLAUMET, G.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c2450-f5cfb3c333c3cd69b4df540dfb92b5985be406e7aad356d0d30321b0323378d23
cites
container_end_page 206
container_issue 3
container_start_page 199
container_title Pharmacy and Pharmacology Communications
container_volume 5
creator MAMAI, A.
BENNEJEAN, C.
RENARD, P.
DELAGRANGE, P.
GUARDIOLA-LEMAITRE, B.
HOWELL, H. E.
VIAUD, M. C.
GUILLAUMET, G.
description A novel series of melatonin analogues based on the benzodioxin nucleus is described. The compounds were prepared in several steps from 2‐carbethoxy‐1,4‐benzodioxin. Some of these derivatives competitively inhibited 2‐[125I]‐iodomelatonin binding to chicken brain and ovine pars tuberalis membranes, albeit with very reduced affinity compared with melatonin.
doi_str_mv 10.1211/146080899128734604
format article
fullrecord <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1211_146080899128734604</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JPHP70</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2450-f5cfb3c333c3cd69b4df540dfb92b5985be406e7aad356d0d30321b0323378d23</originalsourceid><addsrcrecordid>eNqNkM1KAzEUhYMoWKsv4CoP4Gh-58ddFW1tqxZbURAJk0lio9NMmaTY8emdUnHjxsU9l8s931kcAI4xOsUE4zPMYpSiNMswSRPaHmwHdAhiJEowT3dBZ2OIWgfeBwfevyNEEEWkA8x0JX2wYRW0giTqLayqFjrMm_IFn7BXqd1XpWy1ts6fw2njwlx762HuFLywTln3BnvGWGdDA01Vw_YPb3WZh8pZBx90oZehqv0h2DN56fXRz-6Cx-ur2eUgGt_3by5746ggjKPI8MJIWlDaTqHiTDJlOEPKyIxInqVcaoZineS5ojxWSFFECZatUJqkitAuINvcoq68r7URy9ou8roRGIlNU-JvUy0Ub6FPW-rmH4QYTgaTBLVgtAWtD3r9C-b1h4gTmnDxdNcXo_FwNnoeTgSj3w3De0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Substituted 2-Amidomethyl[1,4]benzodioxins: Synthesis and Binding Affinity for the Melatonin Receptors</title><source>Wiley</source><source>Oxford Journals Online</source><creator>MAMAI, A. ; BENNEJEAN, C. ; RENARD, P. ; DELAGRANGE, P. ; GUARDIOLA-LEMAITRE, B. ; HOWELL, H. E. ; VIAUD, M. C. ; GUILLAUMET, G.</creator><creatorcontrib>MAMAI, A. ; BENNEJEAN, C. ; RENARD, P. ; DELAGRANGE, P. ; GUARDIOLA-LEMAITRE, B. ; HOWELL, H. E. ; VIAUD, M. C. ; GUILLAUMET, G.</creatorcontrib><description>A novel series of melatonin analogues based on the benzodioxin nucleus is described. The compounds were prepared in several steps from 2‐carbethoxy‐1,4‐benzodioxin. Some of these derivatives competitively inhibited 2‐[125I]‐iodomelatonin binding to chicken brain and ovine pars tuberalis membranes, albeit with very reduced affinity compared with melatonin.</description><identifier>ISSN: 1460-8081</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/146080899128734604</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><ispartof>Pharmacy and Pharmacology Communications, 1999-03, Vol.5 (3), p.199-206</ispartof><rights>1999 Royal Pharmaceutical Society of Great Britain</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2450-f5cfb3c333c3cd69b4df540dfb92b5985be406e7aad356d0d30321b0323378d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids></links><search><creatorcontrib>MAMAI, A.</creatorcontrib><creatorcontrib>BENNEJEAN, C.</creatorcontrib><creatorcontrib>RENARD, P.</creatorcontrib><creatorcontrib>DELAGRANGE, P.</creatorcontrib><creatorcontrib>GUARDIOLA-LEMAITRE, B.</creatorcontrib><creatorcontrib>HOWELL, H. E.</creatorcontrib><creatorcontrib>VIAUD, M. C.</creatorcontrib><creatorcontrib>GUILLAUMET, G.</creatorcontrib><title>Substituted 2-Amidomethyl[1,4]benzodioxins: Synthesis and Binding Affinity for the Melatonin Receptors</title><title>Pharmacy and Pharmacology Communications</title><description>A novel series of melatonin analogues based on the benzodioxin nucleus is described. The compounds were prepared in several steps from 2‐carbethoxy‐1,4‐benzodioxin. Some of these derivatives competitively inhibited 2‐[125I]‐iodomelatonin binding to chicken brain and ovine pars tuberalis membranes, albeit with very reduced affinity compared with melatonin.</description><issn>1460-8081</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqNkM1KAzEUhYMoWKsv4CoP4Gh-58ddFW1tqxZbURAJk0lio9NMmaTY8emdUnHjxsU9l8s931kcAI4xOsUE4zPMYpSiNMswSRPaHmwHdAhiJEowT3dBZ2OIWgfeBwfevyNEEEWkA8x0JX2wYRW0giTqLayqFjrMm_IFn7BXqd1XpWy1ts6fw2njwlx762HuFLywTln3BnvGWGdDA01Vw_YPb3WZh8pZBx90oZehqv0h2DN56fXRz-6Cx-ur2eUgGt_3by5746ggjKPI8MJIWlDaTqHiTDJlOEPKyIxInqVcaoZineS5ojxWSFFECZatUJqkitAuINvcoq68r7URy9ou8roRGIlNU-JvUy0Ub6FPW-rmH4QYTgaTBLVgtAWtD3r9C-b1h4gTmnDxdNcXo_FwNnoeTgSj3w3De0w</recordid><startdate>199903</startdate><enddate>199903</enddate><creator>MAMAI, A.</creator><creator>BENNEJEAN, C.</creator><creator>RENARD, P.</creator><creator>DELAGRANGE, P.</creator><creator>GUARDIOLA-LEMAITRE, B.</creator><creator>HOWELL, H. E.</creator><creator>VIAUD, M. C.</creator><creator>GUILLAUMET, G.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199903</creationdate><title>Substituted 2-Amidomethyl[1,4]benzodioxins: Synthesis and Binding Affinity for the Melatonin Receptors</title><author>MAMAI, A. ; BENNEJEAN, C. ; RENARD, P. ; DELAGRANGE, P. ; GUARDIOLA-LEMAITRE, B. ; HOWELL, H. E. ; VIAUD, M. C. ; GUILLAUMET, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2450-f5cfb3c333c3cd69b4df540dfb92b5985be406e7aad356d0d30321b0323378d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MAMAI, A.</creatorcontrib><creatorcontrib>BENNEJEAN, C.</creatorcontrib><creatorcontrib>RENARD, P.</creatorcontrib><creatorcontrib>DELAGRANGE, P.</creatorcontrib><creatorcontrib>GUARDIOLA-LEMAITRE, B.</creatorcontrib><creatorcontrib>HOWELL, H. E.</creatorcontrib><creatorcontrib>VIAUD, M. C.</creatorcontrib><creatorcontrib>GUILLAUMET, G.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Pharmacy and Pharmacology Communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MAMAI, A.</au><au>BENNEJEAN, C.</au><au>RENARD, P.</au><au>DELAGRANGE, P.</au><au>GUARDIOLA-LEMAITRE, B.</au><au>HOWELL, H. E.</au><au>VIAUD, M. C.</au><au>GUILLAUMET, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Substituted 2-Amidomethyl[1,4]benzodioxins: Synthesis and Binding Affinity for the Melatonin Receptors</atitle><jtitle>Pharmacy and Pharmacology Communications</jtitle><date>1999-03</date><risdate>1999</risdate><volume>5</volume><issue>3</issue><spage>199</spage><epage>206</epage><pages>199-206</pages><issn>1460-8081</issn><eissn>2042-7158</eissn><abstract>A novel series of melatonin analogues based on the benzodioxin nucleus is described. The compounds were prepared in several steps from 2‐carbethoxy‐1,4‐benzodioxin. Some of these derivatives competitively inhibited 2‐[125I]‐iodomelatonin binding to chicken brain and ovine pars tuberalis membranes, albeit with very reduced affinity compared with melatonin.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><doi>10.1211/146080899128734604</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1460-8081
ispartof Pharmacy and Pharmacology Communications, 1999-03, Vol.5 (3), p.199-206
issn 1460-8081
2042-7158
language eng
recordid cdi_crossref_primary_10_1211_146080899128734604
source Wiley; Oxford Journals Online
title Substituted 2-Amidomethyl[1,4]benzodioxins: Synthesis and Binding Affinity for the Melatonin Receptors
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T11%3A52%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Substituted%202-Amidomethyl%5B1,4%5Dbenzodioxins:%20Synthesis%20and%20Binding%20Affinity%20for%20the%20Melatonin%20Receptors&rft.jtitle=Pharmacy%20and%20Pharmacology%20Communications&rft.au=MAMAI,%20A.&rft.date=1999-03&rft.volume=5&rft.issue=3&rft.spage=199&rft.epage=206&rft.pages=199-206&rft.issn=1460-8081&rft.eissn=2042-7158&rft_id=info:doi/10.1211/146080899128734604&rft_dat=%3Cwiley_cross%3EJPHP70%3C/wiley_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2450-f5cfb3c333c3cd69b4df540dfb92b5985be406e7aad356d0d30321b0323378d23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true