Practical Synthesis of Glaziovianin A, a Cytotoxic Isoflavone, and Its O 7-Propargyl Analogue

Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2014-04, Vol.87 (4), p.544-549
Main Authors: Hayakawa, Ichiro, Shioda, Shuya, Ikedo, Akiyuki, Kigoshi, Hideo
Format: Article
Language:English
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Summary:Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.20130342