Rhodium-catalyzed Synthesis of 1-(Acylamino)isoquinolines through Direct Annulative Coupling of 3-Aryl-1,2,4-oxadiazoles with Alkynes

A Rh(III)-catalyzed direct annulative coupling of 3-aryl-1,2,4-oxadiazoles with alkynes through coordination-assisted C–H activation is developed, providing a facile route to 1-(acylamino)isoquinolines. The oxadiazole ring acts as a directing group as well as an internal oxidant.

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Bibliographic Details
Published in:Chemistry letters 2017-09, Vol.46 (9), p.1347-1349
Main Authors: Nishii, Yuji, Bachon, Anne-Katrin, Moon, Sanghun, Bolm, Carsten, Miura, Masahiro
Format: Article
Language:English
Subjects:
Catalytic C-H Activation
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Summary:A Rh(III)-catalyzed direct annulative coupling of 3-aryl-1,2,4-oxadiazoles with alkynes through coordination-assisted C–H activation is developed, providing a facile route to 1-(acylamino)isoquinolines. The oxadiazole ring acts as a directing group as well as an internal oxidant.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.170536