Label-free Detection of Prostate Specific Antigen at a Screen-printed Immunosensor Modified with a Nanostructured Gold Layer

The development of a disposable immunosensor based on a hybrid gold–carbon screen-printed electrode array is described. The electrodeposition of gold is shown to lead to a field of nanocrystals that facilitates antibody immobilization and enhances electron transfer. A label-free analysis protocol ba...

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Bibliographic Details
Published in:Chemistry letters 2017-12, Vol.46 (12), p.1728-1731
Main Authors: Rawlinson, Sean, Kanyong, Prosper, McConville, Aaron, Fearon, John-Joe, McLaughlin, James A. D., Davis, James
Format: Article
Language:English
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Summary:The development of a disposable immunosensor based on a hybrid gold–carbon screen-printed electrode array is described. The electrodeposition of gold is shown to lead to a field of nanocrystals that facilitates antibody immobilization and enhances electron transfer. A label-free analysis protocol based on ferrocyanide has been developed for the detection of Prostate Specific Antigen in the fg mL−1 range.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.170790