Cellular Uptake and Saccharide Chain Elongation of “Fluoro-amphiphilic” Glycosides

“Fluoro-amphiphilic” glycosides are practical alternatives for the preparation of oligosaccharides. Fluoro-amphiphilic saccharide primers possessing a hydrophilic sugar moiety and a fluorous tag could be taken up by cells and elongated by cellular enzymes. The elongated products were released by cel...

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Bibliographic Details
Published in:Chemistry letters 2005-06, Vol.34 (6), p.856-857
Main Authors: Kasuya, Maria Carmelita Z, Ito, Ayaka, Cusi, Reuben, Sato, Toshinori, Hatanaka, Kenichi
Format: Article
Language:English
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Summary:“Fluoro-amphiphilic” glycosides are practical alternatives for the preparation of oligosaccharides. Fluoro-amphiphilic saccharide primers possessing a hydrophilic sugar moiety and a fluorous tag could be taken up by cells and elongated by cellular enzymes. The elongated products were released by cells to the culture medium and could be easily separated from other components by simple extraction with a fluorous solvent.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.2005.856