β-1.3 Glucan Complex Drastically Suppresses Kidney Clearance of siRNA

siRNA was complexed with a β-1,3-glucan schizophyllan and intravenously administrated into mice. The complexed siRNA escaped renal excretion and remained in the blood. The monocytes in spleen were found to capture the complex and cause the longer residence time of the complexed siRNA, as well as inc...

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Bibliographic Details
Published in:Chemistry letters 2021-10, Vol.50 (10), p.1778-1780
Main Authors: Uno, Atsushi, Arima, Kenji, Ushida, Maki, Katayama, Yuka, Shimazaki, Masako, Amano, Kanako, Namikawa, Reiko, Sakurai, Kazuo
Format: Article
Language:English
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Summary:siRNA was complexed with a β-1,3-glucan schizophyllan and intravenously administrated into mice. The complexed siRNA escaped renal excretion and remained in the blood. The monocytes in spleen were found to capture the complex and cause the longer residence time of the complexed siRNA, as well as increased size of the complex.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.210334