Effects of Pre-Germinated Brown Rice on β-Amyloid Protein-Induced Learning and Memory Deficits in Mice

• Published in: Biological & pharmaceutical bulletin 2004, Vol.27(7), pp.1041-1045
• Main Authors: Mamiya, Takayoshi, Asanuma, Takamasa, Kise, Mitsuo, Ito, Yukihiko, Mizukuchi, Aya, Aoto, Hiromichi, Ukai, Makoto
• Format: Article
• Language: English
• Subjects: Alzheimer's disease; Amyloid beta-Peptides - toxicity; Animals; Germination - physiology; learning and memory; Male; Maze Learning - drug effects; Maze Learning - physiology; Memory Disorders - chemically induced; Memory Disorders - drug therapy; Mice; Mice, Inbred ICR; Oryza; pre-germinated brown rice; preventive effect
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.27.1041

We evaluated the effects of pre-germinated brown rice (hatsuga genmai, PGR) on learning and memory and compared them with those of polished rice or cornstarch. In mice that were fed pellets of polished rice or PGR for two weeks, the learning ability in the Morris water maze test was significantly enhanced compared with mice that were fed cornstarch pellets. In the Y-maze test, the intake of food pellets for two weeks failed to affect spontaneous alternation behavior. β-Amyloid25—35 (Aβ25—35: 3 nmol/mouse, i.c.v.) protein impaired spontaneous alternation behavior in mice that were fed pellets of cornstarch or polished rice. In contrast, PGR pellets prevented the Aβ25—35-induced impairment of spontaneous alternation behavior. These results suggest that polished rice and PGR have facilitating effects on spatial learning. In particular, it is surmised that PGR may prevent Alzheimer's disease associated with Aβ.