Microvascular Vasodilator Plasticity After Acute Exercise

Endothelium-dependent vasodilation is reduced after acute exercise or after high intraluminal pressure in isolated arterioles from sedentary adults but not in arterioles from regular exercisers. The preserved vasodilation in arterioles from exercisers is hydrogen peroxide (H2O2) dependent, whereas r...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2018-01, Vol.46 (1), p.48-55
Main Authors: Robinson, Austin T, Fancher, Ibra S, Mahmoud, Abeer M, Phillips, Shane A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Cardiovascular Diseases - physiopathology
Endothelium, Vascular - physiology
Exercise - physiology
Humans
Hydrogen Peroxide
Microcirculation - physiology
Nitric Oxide - physiology
Sedentary Behavior
Vasodilation - physiology
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Summary:Endothelium-dependent vasodilation is reduced after acute exercise or after high intraluminal pressure in isolated arterioles from sedentary adults but not in arterioles from regular exercisers. The preserved vasodilation in arterioles from exercisers is hydrogen peroxide (H2O2) dependent, whereas resting dilation is nitric oxide (NO) dependent. We hypothesize chronic exercise elicits adaptations allowing for maintained vasodilation when NO bioavailability is reduced.
ISSN:0091-6331
1538-3008
DOI:10.1249/JES.0000000000000130