A Case of Heparin-Induced Thrombocytopenia With Sepsis and Congestive Heart Failure: First Autopsy Report in Japan

• Published in: Circulation Journal 2004, Vol.68(12), pp.1215-1218
• Main Authors: Sawaki, Daigo, Otani, Yoshitaka, Kobayakawa, Naoshi, Sekita, Gaku, Fukushima, Kazuyuki, Takeuchi, Hiroaki, Ogawa, Takafumi, Takemura, Tamiko, Aoyagi, Teruhiko
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Antibodies - blood; Autopsy; Congestive heart failure; Enzyme-Linked Immunosorbent Assay; Fatal Outcome; Guanidines - therapeutic use; Heart Failure - chemically induced; Heart Failure - complications; Heparin - adverse effects; Heparin-induced thrombocytopenia (HIT); Humans; Male; Platelet Count; Platelets; Retreatment; Sepsis; Sepsis - complications; Thrombocytopenia - blood; Thrombocytopenia - chemically induced; Thrombocytopenia - complications; Thrombocytopenia - immunology; Thrombocytopenia - pathology; Thrombosis; Thrombosis - complications; Thrombosis - pathology
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.68.1215

An 84-year-old man was referred to the emergency department with severe dyspnea. Based on his physical findings, electrocardiogram, X-ray and echocardiographic findings, congestive heart failure was suspected and drip infusion of prophylactic heparin against intracardiac thrombosis was commenced together with dopamine, nitroglycerin and furosemide. Diuresis occurred and the pulmonary congestion ameliorated remarkably. Starting on the 20th hospital day, the platelet count was gradually reduced (from 256,000 to 55,000 /μl) and the fibrin degradation product concentration rose (27.6 μg/ml). However, prothrombin time was not prolonged (89%), the concentration of antithrombin III was low -normal (69%) and the fibrinogen concentration was high (650 mg/dl). Thus, heparin-induced thrombocytopenia (HIT), rather than disseminated intravascular coagulation (DIC), was suspected. Heparin was withdrawn on the 24th hospital day and replaced by nafamostat mesilate after which the platelet count was restored to 100,000 /μl. Enzyme-linked immunosorbent assay for HIT antibodies was positive. Unfortunately, the patient died from uncontrolled sepsis on the 29th hospital day. At autopsy, platelet-rich thrombi were found in the small pulmonary arteries and intestinal arteries. No evidence of DIC, such as fibrin-rich thrombosis, was observed. This is the first autopsy report of HIT in Japan. (Circ J 2004; 68: 1215 - 1218)