Effect of Pravastatin on Progression of Coronary Atherosclerosis in Patients After Coronary Artery Bypass Surgery: Pravastatin Coronary Artery Bypass Graft Study

• Published in: Circulation Journal 2005, Vol.69(6), pp.636-643
• Main Authors: Makuuchi, Haruo, Furuse, Akira, Endo, Masahiro, Nakamura, Haruo, Daida, Hiroyuki, Watanabe, Mikio, Ohashi, Yasuo, Hosoda, Yasuyuki, Hosoda, Saichi, Yamaguchi, Hiroshi, Yasui, Hisataka
• Format: Article
• Language: English
• Subjects: Coronary artery bypass graft; Global change score; LDL-cholesterol; Pravastatin; Quantitative coronary angiography
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.69.636

Background Although the anti-atherosclerotic effects of HMG-CoA reductase inhibitors are well known, their specific effect on saphenous vein grafts after coronary artery bypass graft (CABG) operation is not well documented and has not been studied in Japan, so the aim of the present prospective randomized controlled study involving 27 Japanese institutions was to investigate the effects of pravastatin on the progression of atherosclerosis in such grafts and native coronary arteries after CABG. Methods and Results A total of 303 patients who had undergone CABG were randomly assigned to either the pravastatin group (n=168) or the control group (n=167). Paired coronary angiograms were obtained at baseline and at the end of 5-year follow-up in 182 (60%) patients. The low-density lipoprotein cholesterol concentration significantly decreased in the pravastatin group from 141.4 mg/dl to 113.7 mg/dl (-19.6%), compared with 141.1 mg/dl to 133.7 mg/dl (-5.2%) in the control group (p