Effect of Granulocyte Colony-Stimulating Factor Treatment at a Low Dose but for a Long Duration in Patients With Coronary Heart Disease: A Pilot Study

Background In animal models, granulocyte colony-stimulating factor (G-CSF) improves post-infarct cardiac function. However, in pilot studies involving patients with angina and acute myocardial infarction (AMI), G-CSF at a high dose frequently induced coronary occlusion or restenosis, but those at a...

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Published in:Circulation Journal 2006, Vol.70(4), pp.430-437
Main Authors: Suzuki, Koji, Nagashima, Kenshi, Arai, Masazumi, Uno, Yoshihiro, Misao, Yu, Takemura, Genzou, Nishigaki, Kazuhiko, Minatoguchi, Shinya, Watanabe, Sachiro, Tei, Chuwa, Fujiwara, Hisayoshi
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Angina
Granulocyte colony-stimulating factor
Regeneration therapy
Thallium
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Summary:Background In animal models, granulocyte colony-stimulating factor (G-CSF) improves post-infarct cardiac function. However, in pilot studies involving patients with angina and acute myocardial infarction (AMI), G-CSF at a high dose frequently induced coronary occlusion or restenosis, but those at a low dose showed no significant beneficial effect. We hypothesized that a low dose but long duration of G-CSF will have a beneficial effect without serious complications to patients with coronary heart disease. Methods and Results Forty-six patients with angina or AMI were randomly assigned into G-CSF and non-G-CSF control groups, respectively. Recombinant G-CSF was subcutaneously injected once a day for 10 days. The leukocyte counts in the peripheral blood were controlled at approximately 30,000 /μl. One month later, a Thallium-201 single photon emission computed tomography revealed the increased percentage uptake and the reduced extent and severity scores in the G-CSF angina group. In the G-CSF AMI group, the curve between the ejection fraction and peak creatine kinase shifted significantly upward, compared with that of the non-G-CSF AMI group. Serious complications were not observed during the 6 months of observation. Conclusions A low dose but long duration of G-CSF treatment may have a beneficial effect without any serious complications in patients with coronary heart disease. (Circ J 2006; 70: 430 - 437)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.70.430