Diagonal Earlobe Crease are Associated With Shorter Telomere in Male Japanese Patients With Metabolic Syndrome: A Pilot Study

Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atheroscleros...

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Bibliographic Details
Published in:Circulation Journal 2009, Vol.73(2), pp.274-279
Main Authors: Higuchi, Yoshihiro, Maeda, Toyoki, Guan, Jing-Zhi, Oyama, Junichi, Sugano, Masahiro, Makino, Naoki
Format: Article
Language:English
Subjects:
Aging
Atherosclerosis
Earlobe crease
Metabolic syndrome
Telomere length
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Summary:Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis. Methods and Results The mean terminal restriction fragment (TRF) was determined by Southern blot hybridization in the peripheral blood cells of 34 male Japanese patients with metabolic syndrome (MetS) who were under 70 years of age with (n=17) and without (n=17) bilateral ELC, and assessed the relationship of ELC to atherosclerotic cardiovascular disease (AVD). The results showed that the TRF was shorter in the MetS patients with ELC in comparison to age- and risk-factor-matched MetS patients without ELC (7.6±1.1 kbp vs 8.6±1.2 kbp; P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-0267