A NEW PARASYMPATHOMIMETIC AGENT: 1-METHYL-5-CHLOROINDOLINE METHYLBROMIDE

During the investigations of the effect of indoline-derivatives on the smooth muscle have been continued, we have discovered that 1-methyl-5-chloroindoline methylbromide (hereafter referred to as S-6) well contracts the isolated ileum of guinea pig. Thus, the mode of action of S-6 on the guinea pig...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1971, Vol.21(3), pp.311-316
Main Authors: TAKAYANAGI, Issei, IRIKURA, Tsutomu, NISHINO, Keigo, OHKUBO, Hideo
Format: Article
Language:English
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Summary:During the investigations of the effect of indoline-derivatives on the smooth muscle have been continued, we have discovered that 1-methyl-5-chloroindoline methylbromide (hereafter referred to as S-6) well contracts the isolated ileum of guinea pig. Thus, the mode of action of S-6 on the guinea pig ileum has been investigated under various conditions. The aim of this paper is to show that S-6 contracts the isolated ileum of the guinea pig possibly by acting on acetylcholine receptor directly.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.21.311