STUDIES ON THE VASCULAR ACTION OF BRADYKININ

Bradykinin (BK) is widely regarded as a potent vasodilator capable of increasing blood flow, increasing vascular permeability, and lowering systemic blood pressure through microcirculatory dilatation. On the other hand, reports have appeared in the literature which indicate that BK may constrict som...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1971, Vol.21(1), pp.87-95
Main Authors: SEKIYA, Atsushi, NAKASHIMA, Mitsuyoshi, MAEDA, Kiyoshi, YAMAMOTO, Junnosuke, HIRAKO, Ikuo, OYA, Hiroshi
Format: Article
Language:English
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Summary:Bradykinin (BK) is widely regarded as a potent vasodilator capable of increasing blood flow, increasing vascular permeability, and lowering systemic blood pressure through microcirculatory dilatation. On the other hand, reports have appeared in the literature which indicate that BK may constrict some vessels. Lecomte and Trouquet (1), Gersmyer and Spitzbarth (2) and Klupp and Konzett (3) demonstrated the constriction of the lung vessel. Guth et al. (4) and Rowley (5) reported that BK caused venoconstriction of the rabbit ear and rat skin, respectively. Shimamoto et al. (6) also reported the constriction of the rabbit saphenous vein by BK. The present experiments were undertaken to clarify the BK action on the various portions of blood vessel using several methods. Furthermore some tests were tried to study on the mechanism of venoconstrictive action of BK.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.21.87