CENTRALLY MEDIATED CARDIOVASCULAR EFFECTS OF INTRACISTERNAL APPLICATION OF CARBACHOL IN ANESTHETIZED RATS

The pressor response to the intracisternal (i.e.) injection of carbachol (1 μg) in anesthetized rats was analyzed. This response was significantly reduced by the intravenous (i.v.) injection of guanethidine (5 mg), hexamethonium (10 mg) or phen-tolamine (5 mg), and conversely, potentiated by i.v. de...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1976, Vol.26(3), pp.339-346
Main Authors: OZAWA, Hikaru, UEMATSU, Toshio
Format: Article
Language:English
Subjects:
Animals
Atropine - pharmacology
Blood Pressure - drug effects
Carbachol - administration & dosage
Carbachol - pharmacology
Chlorpromazine - pharmacology
Cisterna Magna
Desipramine - pharmacology
Drug Interactions
Hemodynamics - drug effects
Hexamethonium Compounds - pharmacology
Injections
Male
Parasympathomimetics - pharmacology
Propranolol - pharmacology
Rats
Sympatholytics - pharmacology
Vagus Nerve - physiology
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Summary:The pressor response to the intracisternal (i.e.) injection of carbachol (1 μg) in anesthetized rats was analyzed. This response was significantly reduced by the intravenous (i.v.) injection of guanethidine (5 mg), hexamethonium (10 mg) or phen-tolamine (5 mg), and conversely, potentiated by i.v. desmethylimipramine (0.3 mg), while propranolol (0.5 mg) i.v. selectively inhibited the enlargement of pulse pressure and the tachycardia following i.e. carbachol (1 μg). On the other hand, the pressor response to i.e. carbachol (1 μg) was almost completely blocked by i.e. atropine (3 μg) or hexamethonium (500 μg), and significantly reduced by i.e. chlorpromazine (50 μg) but significantly potentiated by i.e. desmethylimipramine (30 μg). The pressor response to i.e. carbachol (1 μg) remained unchanged after sectioning of the bilateral cervical vagal nerves but disappeared after sectioning of the spinal cord (C7-C8). From the above result it is suggested that the pressor response to i.e. carbachol originates in the central muscarinic mechanism, is exerted through the central and peripheral adrenergic mechanisms, and that the sympathetic trunk is the main pathway.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.26.339