EFFECTS OF L-GLUTAMINE ON ACETYLSALICYLIC ACID OR TAUROCHOLIC ACID-INDUCED GASTRIC LESIONS AND SECRETORY CHANGES IN PYLORUS-LIGATED RATS UNDER NORMAL OR STRESS CONDITIONS

An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric mucosa in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1976, Vol.26(4), pp.455-460
Main Authors: OKABE, Susumu, HUNG, Chen-Road, TAKEUCHI, Koji, TAKAGI, Keijiro
Format: Article
Language:English
Subjects:
Animals
Aspirin - pharmacology
Drug Interactions
Gastric Juice - analysis
Gastric Juice - drug effects
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Glutamine - pharmacology
Glutamine - therapeutic use
Hydrogen-Ion Concentration
Male
Potassium - analysis
Pylorus - physiology
Rats
Sodium - analysis
Stomach Ulcer - chemically induced
Stomach Ulcer - etiology
Stomach Ulcer - prevention & control
Stress, Physiological - complications
Stress, Physiological - physiopathology
Taurocholic Acid - pharmacology
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Summary:An oral dosing of either acetylsalicylic acid (ASA) or taurocholic acid (TCA) to pylorus-ligated rats subjected to water-immersion stress produced severe damage to the gastric mucosa in contrast to the irritation observed in non-stressed ones. The irritative activity of ASA or TCA on gastric mucosa under stress was dose-dependent. Stress itself (23°C, 7 hr) did not induce any appreciable changes in gastric mucosa of rats. L-glutamine, given together with ASA or TCA, significantly prevented the potentiated development of ASA- or TCA-induced gastric lesions in stressed rats. L-glutamine also prevented in varying degrees the reduction of acid and increment of Na+ ion in gastric juice accumulated in stressed rats in response to ASA or TCA.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.26.455