PHARMACODYNAMIC ACTIONS OF (S)-2-[4, 5-DIHYDRO5-PROPYL-2 (3H)-FURYLIDENE]-1, 3-CYCLOPENTANEDIONE (OUDENONE)

The pharmacodynamic actions of (S)-2-[4, 5-dihydro-5-propyl-2(3H)-furylidene]-l, 3-cyclopentanedione (oudenone) were studied in both anesthetized animals and isolated organs. Oudenone (10-40 mg/kg i.v.) induced an initial rise in blood pressure followed by a prolonged hypotension in the anesthetized...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1976, Vol.26(5), pp.581-592
Main Authors: OZAWA, Hikaru, KOIDE, Tohru
Format: Article
Language:English
Subjects:
Adrenalectomy
Animals
Autonomic Nervous System - drug effects
Blood Pressure - drug effects
Cats
Cocaine - pharmacology
Cyclopentanes - pharmacology
Dogs
Drug Interactions
Electric Stimulation
Female
Guinea Pigs
Heart Rate - drug effects
Hypertension - physiopathology
In Vitro Techniques
Male
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Myocardial Contraction - drug effects
Nictitating Membrane - drug effects
Norepinephrine - pharmacology
Rabbits
Rats
Regional Blood Flow - drug effects
Reserpine - pharmacology
Spinal Cord - physiology
Time Factors
Vagus Nerve - physiology
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Summary:The pharmacodynamic actions of (S)-2-[4, 5-dihydro-5-propyl-2(3H)-furylidene]-l, 3-cyclopentanedione (oudenone) were studied in both anesthetized animals and isolated organs. Oudenone (10-40 mg/kg i.v.) induced an initial rise in blood pressure followed by a prolonged hypotension in the anesthetized rats. In unanesthetized spontaneously hypertensive rats (SHR), oudenone (5-200 mg/kg p.o.) caused a doserelated decrease in the systolic blood pressure. The initial pressor effect was diminished by pretreatments with phentolamine, guanethidine, hexamethonium and was abolished in the pithed rats. In addition, intracisternal administrations of oudenone (100-600 μg/kg) showed a marked increase in blood pressure in the anesthetized rats, suggesting that the pressor effect may be due to centrally mediated actions. Oudenone, given intra-arterially into the femoral artery (400-800 μg/kg), caused a long-lasting vasodilation in anesthetized dogs. At a relatively high dose (40 mg/kg i.v.), oudenone antagonized all pressor responses to autonomic agents and central vagus nerve stimulation in anesthetized rats and dogs, however, oudenone showed no anti-cholinergic, -histaminergic, beta-adrenergic and adrenergic neuron blocking properties.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.26.581