THE PHARMACOKINETICS OF OCHRATOXIN A IN RATS

The absorption and tissue distribution of ochratoxin A (OCT A) following a single oral dose of OCT A were investigated in adult, male Wistar rats. In experiments concerning excretory patterns of OCT A, 14C-OCT A was used. A relatively large amount of OCT A was found in the circulating blood 48 hours...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1977, Vol.27(5), pp.735-744
Main Authors: SUZUKI, Shigetoshi, SATOH, Tetsuo, YAMAZAKI, Mikio
Format: Article
Language:English
Subjects:
Animals
Bile - analysis
Digestive System - metabolism
Enteritis - chemically induced
Hydrolysis
Kinetics
Male
Ochratoxins - metabolism
Rats
Tissue Distribution
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Summary:The absorption and tissue distribution of ochratoxin A (OCT A) following a single oral dose of OCT A were investigated in adult, male Wistar rats. In experiments concerning excretory patterns of OCT A, 14C-OCT A was used. A relatively large amount of OCT A was found in the circulating blood 48 hours after dosing. The patterns of absorption, tissue distribution and excretion of OCT A were affected by acute catarrhal enteritis produced by OCT A and/or ochratoxin a (OCT a). Quantitative data show that OCT A is distributed mostly in the kidney and this finding is closely associated with the tissue specifity of OCT A-induced nephrotoxicity. OCT A was found to be hydrolyzed to its major metabolite, OCT a by addition of the homogenate of pancreas, duodenum and ileum. Approximately 56% of OCT A administered was excreted in both urine and feces as the unchanged toxin and OCT a during 120 hours following dosing. A relatively larger amount of OCT a was detected as compared with that of OCT A.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.27.735