INFLUENCE OF SURGICAL SYMPATHECTOMY ON GASTRIC SECRETION AND ULCERATION IN RATS

The influences of sympathectomy on gastrointestinal mucosa, gastric secretion, acute or chronic gastric ulcers were studied in rats. Under ether anesthesia, sympathectomy was performed by surgical removal of the celiac ganglion. Surgical sympathectomy per se produced no pathological changes in the g...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1978, Vol.28(2), pp.297-304
Main Authors: KASUYA, Yutaka, MURATA, Teizo, OKABE, Susumu
Format: Article
Language:English
Subjects:
Acetates
Animals
Aspirin
Digestive System - pathology
Gastric Juice - metabolism
Indomethacin
Male
Rats
Reserpine
Serotonin
Stomach Ulcer - chemically induced
Stomach Ulcer - etiology
Stress, Physiological
Sympathectomy
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Summary:The influences of sympathectomy on gastrointestinal mucosa, gastric secretion, acute or chronic gastric ulcers were studied in rats. Under ether anesthesia, sympathectomy was performed by surgical removal of the celiac ganglion. Surgical sympathectomy per se produced no pathological changes in the gastrointestinal tract as determined by macroscopical observation 3, 10 or 20 days after operation. The volume of gastric juice and pepsin output were not influenced by the sympathectomy but gastric acid output was significantly increased in pylorus-ligated rats. The sympathectomy worsened the stress- and the indomethacin-induced ulcer and delayed the healing of chronic gastric ulcers a little but not significantly, and had no deteriorative influence on the reserpine-induccd ulcers. In contrast, Shay ulcers, aspirin-or serotonin-induced ulcers were significantly aggravated by sympathectomy. The loss of H+ ions and gain of Na+ ions in the gastric juice of pylorus-ligated and aspirin-treated rats were not affected by sympathectomy.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.28.297