Gastric Antral Ulcers Induced by a Combination of Acid, Indomethacin and Ischemia in Rats

Gastric antral lesions were produced with hemorrhages by vascular ligation-induced ischemia in the prepyloric regions in rats. Additional treatments with intraluminal acid application and indomethacin markedly aggravated the lesions. Histological examination showed that the incidence of ulcers which...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1985, Vol.38(2), pp.223-226
Main Authors: HIROSE, Fumiaki, MIZUI, Takuji, SHIMONO, Noriko, DOTEUCHI, Masami
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Gastric Mucosa - blood supply
Hydrochloric Acid - toxicity
Indomethacin - toxicity
Ischemia - complications
Male
Medical sciences
Pharmacology. Drug treatments
Pyloric Antrum - pathology
Rats
Rats, Inbred Strains
Stomach Ulcer - etiology
Toxicity: digestive system
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Summary:Gastric antral lesions were produced with hemorrhages by vascular ligation-induced ischemia in the prepyloric regions in rats. Additional treatments with intraluminal acid application and indomethacin markedly aggravated the lesions. Histological examination showed that the incidence of ulcers which penetrated the muscularis mucosae was nearly 100% upon treatment with a combination of acid, indomethacin and ischemia. This model provides a useful too! for studying gastric ulcer etiology.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.38.223