Alpha-Human Atrial Natriuretic Peptide (α-hANP) Prevents Pulmonary Edema Induced by Arachidonic Acid Treatment in Isolated Perfused Lung from Guinea Pig

Protective effect of α-human atrial natriuretic peptide (α-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of α-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 jug of arachidon...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1987, Vol.44(2), pp.211-214
Main Authors: INOMATA, Norio, OHNUMA, Norio, FURUYA, Mayumi, HAYASHI, Yujiro, KANAI, Yasushi, ISHIHARA, Takafumi, NOGUCHI, Teruhisa, MATSUO, Hisayuki
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acids
Atrial Natriuretic Factor - metabolism
Atrial Natriuretic Factor - pharmacology
Biological and medical sciences
Cardiology. Vascular system
Chronic cor pulmonale
Guinea Pigs
Heart
Humans
In Vitro Techniques
Kinetics
Lung - metabolism
Male
Medical sciences
Pneumology
Pulmonary Edema - chemically induced
Pulmonary Edema - prevention & control
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
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Summary:Protective effect of α-human atrial natriuretic peptide (α-hANP) on pulmonary edema was investigated using an isolated perfused lung model. Infusion of α-hANP (1.7 to 22 ng/ml or 0.56 to 7.3 nM) prevented the edema induced in isolated lung from guinea pig by repeated treatment of 50 jug of arachidonic acid at 30 min intervals via the pulmonary artery. The antiedematic action of α-hANP was considered to be receptor mediated because the effective concentration was close to the Kd value of the binding of the ANP receptors in the lung homogenate.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.44.211