Potentiation of β-Adrenergic Function by Saiboku-To and Bakumondo-To in Canine Bronchial Smooth Muscle

To determine the effects of the Kampo drugs Saiboku-to, Bakumondo-to and Orengedoku-to on β-adrenergic function in airway smooth muscle, we studied isolated canine bronchial segments under isometric conditions in vitro. Incubation of tissues with these drugs did not alter the contractile responses t...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1993, Vol.61 (4), p.319-324
Main Authors: Tamaoki, Jun, Chiyotani, Atsushi, Takeyama, Kiyoshi, Kanemura, Toshinori, Sakai, Noritaka, Konno, Kimio
Format: Article
Language:English
Subjects:
Airway smooth muscle
Asthma
Bakumondo-to
Saiboku-to
β-Adrenoceptor
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Summary:To determine the effects of the Kampo drugs Saiboku-to, Bakumondo-to and Orengedoku-to on β-adrenergic function in airway smooth muscle, we studied isolated canine bronchial segments under isometric conditions in vitro. Incubation of tissues with these drugs did not alter the contractile responses to acetylcholine and histamine. The relaxation of tissues precontracted with acetylcholine induced by isoproterenol was augmented by Saiboku-to and Bakumondo-to, so that the concentration of isoproterenol required to produce a half-maximal effect (IC50) was decreased from 4.6±0.5 × 10-8M to 1.9±1.0 × 10-8 M (P
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.61.319