Centrally Applied Bombesin Increases Nerve Activity of Both Sympathetic and Adrenal Branch of the Splanchnic Nerves

We reported that centrally applied bombesin probably excites both the gastric sympathetic and adrenomedullary systems and thus induces inhibition of gastric acid secretion. In the present study, therefore, we examined whether or not centrally applied bombesin directly affects sympathetic nerve activ...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1995, Vol.68(2), pp.227-230
Main Authors: Okuma, Yasunobu, Yokotani, Kunihiko, Osumi, Yoshitsugu
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Adrenal Medulla - drug effects
Adrenal Medulla - innervation
Adrenal nerve activity
Anesthesia
Animals
Biological and medical sciences
Blood Pressure - drug effects
Bombesin
Bombesin - administration & dosage
Bombesin - pharmacology
Catecholaminergic system
Injections, Intraventricular
Male
Medical sciences
Neurons, Efferent - drug effects
Neurons, Efferent - ultrastructure
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Nitroprusside - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Wistar
Splanchnic Nerves - drug effects
Splanchnic Nerves - ultrastructure
Sympathetic nerve activity
Sympathetic Nervous System - drug effects
Sympathetic Nervous System - ultrastructure
Sympathomimetics - administration & dosage
Sympathomimetics - pharmacology
Urethane
Vasodilator Agents - pharmacology
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Summary:We reported that centrally applied bombesin probably excites both the gastric sympathetic and adrenomedullary systems and thus induces inhibition of gastric acid secretion. In the present study, therefore, we examined whether or not centrally applied bombesin directly affects sympathetic nerve activities in rats anesthetized with urethane. Intracerebroventricular administration of bombesin (0.3 and 3.0 nmol) increased discharge rates of the sympathetic branch as well as those of the adrenal branch of preganglionic greater splanchnic nerves. These effects were not secondary to changes in arterial blood pressure by bombesin. In conclusion, centrally applied bombesin directly activates both the sympathetic and adrenomedullary systems.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.68.227