The Effect of Acute Cold Exposure and Norepinephrine on Uncoupling Protein Gene Expression in Brown Adipose Tissue of Monosodium Glutamate-Obese Mice

Abnormal regulation of mitochondrial uncoupling protein (UCP) gene expression was studied in brown adipose tissue (BAT) of monosodium glutamate (MSG)-induced obese mice. UCP mRNA levels in control mice increased markedly after acute cold exposure; however, MSG-obese mice showed an impaired response....

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1998, Vol.77(3), pp.247-249
Main Authors: Tsukahara, Fujiko, Uchida, Yoko, Ohba, Ken-ichi, Ogawa, Akira, Yoshioka, Toshimasa, Muraki, Takamura
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - metabolism
Animals
Brown adipose tissue
Carrier Proteins - genetics
Cold Temperature
Gene Expression Regulation - drug effects
Ion Channels
Membrane Proteins - genetics
Mice
Mitochondria - metabolism
Mitochondrial Proteins
Monosodium glutamate
Norepinephrine - pharmacology
Obesity - chemically induced
Obesity - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sodium Glutamate - toxicity
Uncoupling protein
Uncoupling Protein 1
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Summary:Abnormal regulation of mitochondrial uncoupling protein (UCP) gene expression was studied in brown adipose tissue (BAT) of monosodium glutamate (MSG)-induced obese mice. UCP mRNA levels in control mice increased markedly after acute cold exposure; however, MSG-obese mice showed an impaired response. In contrast, an injection of norepinephrine (NE) induced a comparable increase in UCP mRNA levels in control and MSG-obese mice. These results suggest that the impairment in the cold-induced increase in UCP mRNA is due to a deficient sympathetic input to BAT and/or to a diminished response of BAT to endogenous NE, which constitutes the mechanism of impaired thermoregulation in obese mice in a cold environment.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.77.247