A Comparative Study of the Fluoroquinolone Antibacterial Agents on the Action Potential Duration in Guinea Pig Ventricular Myocardia

We examined the effects of ten fluoroquinolone antibacterial agents, levofloxacin, sita-floxacin, trovafloxacin, ciprofloxacin, gemifloxacin, tosufloxacin, gatifloxacin, grepafloxacin, moxifloxacin and sparfloxacin, on action potentials recorded from guinea pig ventricular myocardia. Sparfloxacin pr...

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Bibliographic Details
Published in:Japanese journal of pharmacology 2001, Vol.87 (3), p.231-234
Main Authors: Hagiwara, Takehiro, Satoh, Sumie, Kasai, Yoshio, Takasuna, Kiyoshi
Format: Article
Language:English
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Summary:We examined the effects of ten fluoroquinolone antibacterial agents, levofloxacin, sita-floxacin, trovafloxacin, ciprofloxacin, gemifloxacin, tosufloxacin, gatifloxacin, grepafloxacin, moxifloxacin and sparfloxacin, on action potentials recorded from guinea pig ventricular myocardia. Sparfloxacin prolonged action potential duration (APD) by about 8% at 10 μ M and 41% at 100 μ M. Gatifloxacin, grepafloxacin and moxifloxacin also prolonged APD at 100 μ M by about 13%, 24% and 25%, respectively. In contrast, levofloxacin, sitafloxacin, trovafloxacin, ciprofloxacin, gemifloxacin and tosufloxacin had little or no APD-prolonging effect at concentrations as high as 100 μ M. These findings suggest that there are differences in potency to prolong QT interval among the fluoroquinolones.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.87.234