The effect of oleanolic acid on sperm motion characteristics and fertility of male Wistar rats

The study was designed to examine the effect of oleanolic acid on cauda epididymal sperm motion using a computer-aided sperm analysis system and to elucidate the relationship between sperm motion and fertility, as a tool for contraceptive studies. Oleanolic acid-polyvinylpyrrollidone suspension was...

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Bibliographic Details
Published in:Laboratory animals (London) 2002-10, Vol.36 (4), p.432-437
Main Authors: Mdhluli, M C, van der Horst, G
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Contraceptive Agents, Male - administration & dosage
Contraceptive Agents, Male - toxicity
Female
Fertility - drug effects
Image Processing, Computer-Assisted
Male
Oleanolic Acid - administration & dosage
Oleanolic Acid - toxicity
Random Allocation
Rats
Rats, Wistar
Recovery of Function
Sperm Immobilizing Agents - administration & dosage
Sperm Immobilizing Agents - toxicity
Sperm Motility - drug effects
Sperm Motility - physiology
Time Factors
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Summary:The study was designed to examine the effect of oleanolic acid on cauda epididymal sperm motion using a computer-aided sperm analysis system and to elucidate the relationship between sperm motion and fertility, as a tool for contraceptive studies. Oleanolic acid-polyvinylpyrrollidone suspension was orally administered to adult male Wistar rats for 30 days, followed by a 14-day drug withdrawal from half of the rats in the group. Control rats received only polyvinylpyrrollidone. All males were mated with untreated females. Treated males failed to impregnate females, whereas control and oleanolic acid withdrawn males achieved 100% pregnancies. Sperm motion analysed on the Sperm Motility Quantifier (SMQ) showed significant differences in linearity (P < 0.001) and wobble (P < 0.01) between control and treated groups. However, the curvilinear velocities were not significantly different (P > 0.05) among all the groups. Sperm motility patterns verified differences among kinematic parameters.
ISSN:0023-6772
1758-1117
DOI:10.1258/002367702320389107