Hypoxia in head and neck cancer

A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology w...

Full description

Saved in:
Bibliographic Details
Published in:British journal of radiology 2006-10, Vol.79 (946), p.791-798
Main Authors: ISA, A. Y, WARD, T. H, WEST, C. M. L, SLEVIN, N. J, HOMER, J. J
Format: Article
Language:English
Subjects:
Antibiotics, Antineoplastic - therapeutic use
Basic Helix-Loop-Helix Transcription Factors - analysis
Biological and medical sciences
Biomarkers - analysis
Cell Hypoxia
Comet Assay
Head and Neck Neoplasms - blood supply
Head and Neck Neoplasms - radiotherapy
Hemoglobins - metabolism
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - analysis
Medical sciences
Microelectrodes
Nitroimidazoles - pharmacokinetics
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Oxygen - administration & dosage
Oxygen - analysis
Positron-Emission Tomography - methods
Prognosis
Radiation-Sensitizing Agents - therapeutic use
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A high level of hypoxia in solid tumours is an adverse prognostic factor for the poor outcome of cancer patients following treatment. This review describes the status of research into finding a practical method for measuring hypoxia and treating hypoxic tumours. The application of such methodology would enable the selection of head and neck cancer treatment based on an individual's tumour oxygenation status. This individualization would include the selection not only of surgery or radiotherapy, but also of novel hypoxia-modification strategies.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/17904358