Molecular imaging using hyperpolarized 13C

MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhan...

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Bibliographic Details
Published in:British journal of radiology 2003-12, Vol.76 Spec No 2 (suppl_2), p.S118-S127
Main Authors: Golman, K, Olsson, L E, Axelsson, O, Månsson, S, Karlsson, M, Petersson, J S
Format: Article
Language:English
Subjects:
Animals
Carbon Isotopes - analysis
Humans
Lung Diseases - diagnosis
Magnetic Resonance Imaging - methods
Male
Models, Chemical
Rabbits
Thermodynamics
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Summary:MRI provides unsurpassed soft tissue contrast, but the inherent low sensitivity of this modality has limited the clinical use to imaging of water protons. With hyperpolarization techniques, the signal from a given number of nuclear spins can be raised more than 100 000 times. The strong signal enhancement enables imaging of nuclei other than protons, e.g. (13)C and (15)N, and their molecular distribution in vivo can be visualized in a clinically relevant time window. This article reviews different hyperpolarization techniques and some of the many application areas. As an example, experiments are presented where hyperpolarized (13)C nuclei have been injected into rabbits, followed by rapid (13)C MRI with high spatial resolution (scan time
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/26631666