The Changes of Rat Blood-Brain Barrier Permeability and Expression of Heat Shock Protein 70 after Infrasonic Damage

• Published in: Journal of Low Frequency Noise, Vibration and Active Control Vibration and Active Control, 2000-06, Vol.19 (2), p.93-99
• Main Authors: Fei, Zhou, Zhang, Xiang, Wang, Xiao-Feng, Li, Zhi-Gang, Lu, Pei-Ling, Liu, Xian-Zhen, Chen, Jing-Zao, Jia, Ke-Yong
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; Fundamental and applied biological sciences. Psychology; Vertebrates: nervous system and sense organs
• ISSN: 0263-0923; 1461-3484; 2048-4046
• DOI: 10.1260/0263092001492840

To study the changes of blood-brain barrier (BBB) permeability and the heat shock protein 70(HSP70) after infrasonic damage, 40 SD rats were randomized into control, infrasonic damage 1 time, 7 times and 14 times groups. 8Hz 120dB Infrasound of 8Hz frequency and 120dB level was applied to the infrasonic damage groups for 2 hours once according to the planned schedule. The right frontal cortex was sampled for immunohistological examination. Under the electronic microscope changes of cerebral ultrastructure and BBB permeability were observed. Results showed that with the increase in the times of infrasonic damage, cerebral ultrastructure became more aggravated. The 1 and 7 times group shared the same changes of BBB permeability in which tight conjunction opened and Lanthanum nitrate particles passed BBB into the brain tissue. Moreover, the 14 times group has more radical changes in which a great deal of Lanthanum nitrate particles exist in the brain tissue (P