Fetal Loss and Hyposulfataemia in Pregnant NaS1 Transporter Null Mice

Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1-/-) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during pregnancy and to determine the physiological consequences of mate...

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Bibliographic Details
Published in:Journal of Reproduction and Development 2011, Vol.57(4), pp.444-449
Main Authors: DAWSON, Paul Anthony, SIM, Pearl, SIMMONS, David Gordon, MARKOVICH, Daniel
Format: Article
Language:English
Subjects:
Placenta
Pregnancy
Sulfate
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Summary:Sulfate is important for growth and development, and is supplied from mother to fetus throughout pregnancy. We used NaS1 sulfate transporter null (Nas1-/-) mice to investigate the role of NaS1 in maintaining sulfate homeostasis during pregnancy and to determine the physiological consequences of maternal hyposulfataemia on fetal, placental and postnatal growth. We show that maternal serum (≤0.5 mM), fetal serum (
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.10-173K