Involvement of Neurokinin Receptors in the Control of Pulsatile Luteinizing Hormone Secretion in Rats

It has recently been shown that neurokinin B, a tachykinin, is associated with GnRH pulse generation in sheep and goats. The aim of the present study was to clarify the role of tachykinin receptors in the control of LH secretion in rats. To this end, we evaluated the effect of CS-003, an antagonist...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Reproduction and Development 2011, Vol.57(3), pp.409-415
Main Authors: NORITAKE, Ken-ichi, MATSUOKA, Toshiki, OHSAWA, Tetsuya, SHIMOMURA, Kazuhiro, SANBUISSHO, Atsushi, UENOYAMA, Yoshihisa, MAEDA, Kei-ichiro, TSUKAMURA, Hiroko
Format: Article
Language:English
Subjects:
Luteinizing hormone
Neurokinin
Rat
Receptor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has recently been shown that neurokinin B, a tachykinin, is associated with GnRH pulse generation in sheep and goats. The aim of the present study was to clarify the role of tachykinin receptors in the control of LH secretion in rats. To this end, we evaluated the effect of CS-003, an antagonist for all three neurokinin receptors (NK1, NK2 and NK3 receptors), on pulsatile LH secretion in both sexes of rats with different routes of administration. Both oral and third ventricular administration of CS-003 suppressed LH secretion in both sexes of gonadectomized animals. Furthermore, intact male rats with oral administration of CS-003 showed decreased serum testosterone levels, which might be due to suppressed LH secretion. None of the three subtype-specific neurokinin receptor antagonists showed a significant effect on LH secretion in ovariectomized rats when each antagonist was singly administered. The present results suggest that neurokinins play a role in the control of pulsatile GnRH/LH secretion via multiple neurokinin receptors in both male and female rats.
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.11-002S