Effects of prostaglandin F2alpha and nitric oxide on the secretory function of bovine luteal cells

The objective of the present study was to investigate the influence of prostaglandin F2alpha (PGF2alpha) and nitric oxide (NO) on production of steroids and PGs by culturing bovine luteal cells obtained from ovaries on days 8-12 of the estrous cycle with a nitric oxide (NO) donor (Spermine NONOate),...

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Bibliographic Details
Published in:The Journal of reproduction and development 2004, Vol.50 (4), p.411-417
Main Authors: Korzekwa, A. (Institute of Animal Reproduction and Food Research, Olsztyn (Poland)), Jaroszewski, J.J, Bogacki, M, Deptula, K.M, Maslanka, T.S, Acosta, T.J, Okuda, K, Skarzynski, D.J
Format: Article
Language:English
Subjects:
CATTLE
CORPUS LUTEUM
COWS
IN VITRO EXPERIMENTATION
NITRIC OXIDE
OESTROGENS
PROGESTERONE
PROSTAGLANDINS
SECRETION
TESTOSTERONE
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Summary:The objective of the present study was to investigate the influence of prostaglandin F2alpha (PGF2alpha) and nitric oxide (NO) on production of steroids and PGs by culturing bovine luteal cells obtained from ovaries on days 8-12 of the estrous cycle with a nitric oxide (NO) donor (Spermine NONOate), and a NO synthase inhibitor (NG-nitro-L-arginine methyl ester dihydrochloride: L-NAME). When the cells were exposed for 24 h to PGF2alpha (10E-7-10E-5 M), production of progesterone (P4) increased significantly at all doses used (P
ISSN:0916-8818
1348-4400
DOI:10.1262/jrd.50.411