The burden of BRCA1 and BRCA2 gene mutations among Vietnamese women and their associated factors: A protocol for a systematic review and meta-analysis [version 1; peer review: awaiting peer review]

• Published in: F1000 research 2022, Vol.11, p.852
• Main Authors: Tran, Phuc Thai, Tran, Duc Quang, Vu, Chi Thi Quynh, Phan, Quang Ngoc, Nguyen, Anh Thi Thu
• Format: Article
• Language: English
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.123884.1

Background: BReast CAncer gene (BRCA)1 and BRCA2 mutation carriers are frequently provided genetic counselling. A precise estimation of the prevalence of BRCA gene mutations is essential to provide an appropriate risk prediction. However, the data in Vietnam is ambiguous and include unreliable risk factors from individual studies. Hence, the objective of this protocol is to provide a method to synthesize evidence pertaining to the proportion of BRCA mutations among Vietnamese women and their risk factors for cancer. Methods: PRISMA-P was followed in developing and reporting this protocol. From the databases' inception until June 2023, a comprehensive search will be undertaken in electronic PubMed and Scopus databases. In two stages, title/abstract screening and full-text screening, two independent authors will assess all retrieved articles for inclusion. This review includes papers providing the relevant results reflecting the prevalence of BRCA gene mutations in Vietnamese women who are at least 18 years old with or without cancer. Predefined selection criteria will be used to establish each publication's eligibility. Using the Newcastle-Ottawa Scale and Cochrane Risk of Bias tools, the quality of included studies will be assessed, and overall evidence quality will be appraised using the GRADE approach. All pertinent data from the included articles will be entered into an Excel spreadsheet for meta-analysis, which will be imported into Rstudio. Meta-analyses using random effects will be used to obtain the pooled percentages. The chi-squared test and I 2 parameter will be used to evaluate heterogeneity. Publication bias will be investigated visually using funnel plots for asymmetry and Egger's statistical tests. Conclusions: Based on the prevalence of BRCA muations and its associated comprehensive and specific risk factors, we hope our findings will provide a reference for future strategies to build an effective treatment plan and manage the risk of cancer development. Registration: PROSPERO ( CRD42022340152; 30 June 2022).